Aldose reactase inhibitor

Abstract

PURPOSE: To obtain an aldose reactase inhibitor containing a specific compound such as liquiritin, liquiritigenin, etc., as an active ingredient and useful in treatment for various complications of diabetes such as cataract, retinopathy, nervous disorder, kidney disease, etc. CONSTITUTION: A compound expressed by the formula (R is H or glucose; R' is H or OH), namely liquirithin (R=glucose, R'=H), liquiritigenin (R=H, R'=H), choerospondin (R=glucose, R'=OH) or naringenin (R=H, R'=OH) is contained as an active ingredient. Said compound is an active ingredient contained in Licorice. The Licorice is extracted with water or/and alcohols and the extract solution is then subjected to column chromatography containing Sephadex, etc., used as a carrier to provide each fraction and water-methanol (1:1) elution part and methanol elution part are subjected to column chromatography and thin layer chromatography to afford each compound. COPYRIGHT: (C)1988,JPO&Japio

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Cited By (7)

    Publication numberPublication dateAssigneeTitle
    EP-0270690-A1June 15, 1988Dainippon Ink And Chemicals, Inc., Nippon Hypox Laboratories IncorporatedDrug for treatment and prophylaxis of kidney and liver diseases
    EP-0516860-A1December 09, 1992TSUMURA & CO.Derive de benzopyrone et inhibiteur de reductase d'aldose contenant ce derive en tant qu'ingredient actif
    KR-100592482-B1June 26, 2006경북대학교 산학협력단감초 및 감초추출물 중의 리퀴리티게닌 함량을 증강하는방법과 추출물에서의 활성화합물 정제방법
    US-5455267-AOctober 03, 1995Tsumura & Co.Chromone derivative, and aldose reductase inhibitor comprising said compound as active component
    US-5627204-AMay 06, 1997Tsumura & CompanyChromone derivative, and aldose reductase inhibitor comprising said compound as active component
    US-5675023-AOctober 07, 1997Tsumura & Co.Chromone derivative, and aldose reductase inhibitor comprising said compound as active component
    WO-0015174-A3July 13, 2000Korea Inst Sci & TechBioflavonoide utilise en tant qu'agent permettant d'abaisser le taux de glycemie